81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor rein a physiologically häufig pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
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Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
If you have already acquired a copyright hinein a different country, ur team will help you with transferring it and will advise you on your way to obtaining a German driving permit.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.
You are allowed to have 10 minus points. You have failed the test if you get 11 or more negativ points. If you incorrectly answer two questions each with five minus points, you have also failed the test in spite of not exceeding the maximum number of negativ points; in Class B, questions with 5 points have a greater relevance rein the theoretical test.
Where can I find an economical first-aid course? We also offer courses daily in the Munich city area. They are all held rein classrooms adjacent to U/S-Bahn stations. Moosach
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Next to the Ostfriedhof bus and tram stop Can I take a trial lesson hinein the theoretical Hier course rein order to get an impression of the atmosphere?
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